Tolerance | Cannabis Wiki
Tolerance is a reaction to dose (such as cannabis) in which the effects are progressively reduced, requiring an increase in dose in order to achieve the desired effect; resistance to the effect of a drug.
The individual develops a decreased sensitivity to subsequent doses of the drug and requires increasingly larger doses to get the full effect of the drug. Tolerance is also a characteristic of drug addiction.
When a drug is given for the first time by whatever method, it is called the initial dose. The initial dose is also known as the first dose.